Prognostic value of p53 protein expression for patients with gastric cancer – a multivariate analysis
1999
Prognostic Value of p53 Protein Expression in Gastric Cancer
Sample size: 427
publication
Evidence: moderate
Author Information
Author(s): Maehara Y, Tomoda M, Hasuda S, Kabashima A, Tokunaga E, Kakeji Y, Sugimachi K
Primary Institution: Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
Hypothesis
The study investigates the prognostic role of p53 protein expression in patients with gastric cancer.
Conclusion
Higher p53 expression is associated with worse prognosis in gastric cancer patients.
Supporting Evidence
- p53 expression was detected in 38.6% of gastric cancers.
- Patients with p53-positive tumors had a 5-year survival rate of 43.3%.
- The presence of p53 expression was significantly correlated with worse prognosis.
Takeaway
This study found that patients with a certain protein in their cancer cells tend to do worse after treatment.
Methodology
The study used multivariate analysis on tumor sections from 427 gastric cancer patients to assess p53 expression and its correlation with survival.
Participant Demographics
Japanese patients with gastric cancer.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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