Reciprocal Roles of Angiotensin II and Angiotensin II Receptors Blockade (ARB) in Regulating Cbfa1/RANKL via cAMP Signaling Pathway: Possible Mechanism for Hypertension-Related Osteoporosis and Antagonistic Effect of ARB on Hypertension-Related Osteoporosis
2011
How Angiotensin II Affects Bone Health and the Role of ARB
publication
Author Information
Author(s): Guan Xiao-Xu, Zhou Yi, Li Ji-Yao
Primary Institution: State Key Laboratory of Oral Diseases, Sichuan University
Hypothesis
Angiotensin II plays an important role in hypertension-related osteoporosis, and ARB may antagonize its effects on bone.
Conclusion
The study suggests that angiotensin II negatively impacts bone health, while ARB may help counteract these effects.
Supporting Evidence
- Hypertension is linked to increased calcium loss and osteoporosis.
- Angiotensin II can negatively affect bone formation.
- ARB may help increase bone mass and reduce fracture risk.
Takeaway
High blood pressure can hurt your bones, but a certain medicine might help protect them.
Digital Object Identifier (DOI)
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