Sordarin, an antifungal agent with a unique mode of action
2008
Sordarin: A Unique Antifungal Agent
publication
Evidence: moderate
Author Information
Author(s): Liang Huan
Primary Institution: The University of British Columbia
Hypothesis
Sordarin acts on elongation factor 2 (EF2) to inhibit protein synthesis in fungi.
Conclusion
Sordarin shows strong antifungal activity by inhibiting protein synthesis in pathogenic fungi.
Supporting Evidence
- Sordarin inhibits protein synthesis in fungi by stabilizing the ribosome/EF2 complex.
- Sordarin has shown strong activity against various pathogenic fungi.
- Total syntheses of sordarin and its analogs have been achieved by multiple research groups.
Takeaway
Sordarin is a special medicine that helps fight fungal infections by stopping the fungi from making proteins they need to grow.
Methodology
The review discusses total syntheses of sordarin and its analogs, focusing on their unique mechanisms and modifications.
Limitations
The review does not provide extensive toxicity tests for some sordarin analogs.
Digital Object Identifier (DOI)
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