N6-METHYLDEOXYADENOSINE (N6MEDA) IS ASSOCIATED WITH AGING
2024
N6-methyldeoxyadenosine and Aging
publication
Author Information
Author(s): Tretyakova Natalia
Primary Institution: University of Minnesota, Minneapolis, Minnesota, United States
Hypothesis
N6medA is involved in human aging and Alzheimer's Disease.
Conclusion
N6medA levels increase with age and are associated with Alzheimer's Disease.
Supporting Evidence
- N6medA is positively correlated with chronological age in the prefrontal cortex.
- N6medA levels trend upwards in mild cognitive impairment and Alzheimer's Disease.
- Increased adenine methylation in AD is found in genes related to neurological function.
Takeaway
N6medA is a special mark in DNA that seems to grow as people get older and might be linked to Alzheimer's.
Methodology
Developed an ultrasensitive isotope dilution nanoLC-methodology for N6medA in genomic DNA.
Digital Object Identifier (DOI)
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