FTO Gene and Obesity in Children with Down Syndrome
Author Information
Author(s): Mourad Shereen A., El-Farahaty Reham M, Atwa Mohamed A., Yahia Sohier, El-Gilany Abdel-Hady, Elzeiny Ahmed A., Elhennawy Eman S.
Primary Institution: Mansoura University
Hypothesis
Is there an association between the FTO rs17817449 gene polymorphism and obesity-related markers in children with Down syndrome?
Conclusion
The study found that the FTO rs17817449 genetic variant is associated with overweight and obesity in children with Down syndrome.
Supporting Evidence
- Children with Down syndrome have higher rates of obesity compared to non-DS children.
- The FTO rs17817449 T allele was found more frequently in overweight and obese children.
- Genotypes GT and TT of the FTO gene were identified as independent risk factors for obesity in DS children.
Takeaway
This study shows that a specific gene can make some kids with Down syndrome more likely to be overweight or obese.
Methodology
A case-control study with genotyping of the FTO gene and assessment of serum lipid and thyroid profiles.
Limitations
The study had a small sample size and was conducted at a single center.
Participant Demographics
100 children with Down syndrome, aged under 18, divided into non-obese, overweight, and obese groups.
Statistical Information
P-Value
0.0099
Statistical Significance
p=0.0099
Digital Object Identifier (DOI)
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