Rapid Spread of SIV After Rectal Infection
Author Information
Author(s): Ribeiro dos Santos Patricia, Rancez Magali, Prétet Jean-Luc, Michel-Salzat Alice, Messent Valérie, Bogdanova Anna, Couëdel-Courteille Anne, Souil Evelyne, Cheynier Rémi, Butor Cécile
Primary Institution: Laboratoire de Transmission et Dissémination Virales, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
Hypothesis
How does SIV spread in the body after rectal infection?
Conclusion
SIV can enter and spread from the rectum to lymph nodes in less than four hours.
Supporting Evidence
- SIV DNA was detected in the rectum as early as four hours post infection.
- Control macaques inoculated with heat-inactivated virus were consistently negative for SIV.
- Over 60% of lymphoid aggregates were positive for SIV DNA at four and sixteen hours post infection.
- SIV rapidly disseminates from the mucosa to the lymph nodes within four hours.
Takeaway
When SIV enters the body through the rectum, it can quickly spread to other parts, like lymph nodes, in just a few hours.
Methodology
Rhesus macaques were inoculated with SIV and necropsied at various time points to analyze viral spread using PCR and immunohistochemistry.
Limitations
The study was conducted in animal models, which may not fully replicate human responses.
Participant Demographics
Nineteen adult male rhesus macaques were used in the study.
Digital Object Identifier (DOI)
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