Local apoptosis boosts collagen production in lung fibrosis
Author Information
Author(s): Peng Xueyan, Mathai Susan K, Murray Lynne A, Russell Thomas, Reilkoff Ronald, Chen Qingsheng, Gulati Mridu, Elias Jack A, Bucala Richard, Gan Ye, Herzog Erica L
Primary Institution: Yale University School of Medicine
Hypothesis
Are apoptotic cell death responses essential for the accumulation of collagen-producing cells in lung fibrosis?
Conclusion
Preventing collagen production by monocytes through apoptosis modulation may help treat pulmonary fibrosis.
Supporting Evidence
- CD45+Col-I+ cells in the lung express monocyte lineage markers.
- Inhibition of apoptosis significantly reduces CD45+Col-I+ cells.
- Increased apoptosis and CD45+Col-I+ cells are found in patients with fibrotic lung disease.
Takeaway
When cells in the lungs die, it helps other cells make more collagen, which can lead to lung problems. Stopping this process might help treat those issues.
Methodology
Used a murine model of pulmonary fibrosis and assessed the role of apoptosis in collagen-producing cells.
Participant Demographics
Included patients with idiopathic pulmonary fibrosis and connective tissue disease-related interstitial lung disease.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website