Nicotinamide and Fluosol DA/Carbogen for Tumor Reoxygenation
Author Information
Author(s): D.J. Chaplin, M.R. Horsman, D.S. Aoki
Primary Institution: B.C. Cancer Research Centre
Hypothesis
Can a combination of Nicotinamide and Fluosol DA/Carbogen effectively reoxygenate hypoxic tumor cells?
Conclusion
The combination of Nicotinamide and Fluosol DA/Carbogen significantly enhances the radiation response of both acutely and chronically hypoxic tumor cells.
Supporting Evidence
- Nicotinamide significantly reduces acute hypoxia in tumors.
- Combination treatment resulted in an enhancement factor of 1.6.
- Fluosol DA/Carbogen alone did not significantly enhance radiation response.
Takeaway
This study shows that using Nicotinamide with Fluosol DA and Carbogen can help tumors get more oxygen, making them more sensitive to radiation treatment.
Methodology
Mice with SCCVII or KHT tumors were treated with Nicotinamide and/or Fluosol DA/Carbogen before radiation, and tumor cell survival was assessed using clonogenic assays.
Limitations
The enhancement of radiation response from Fluosol DA/Carbogen did not reach statistical significance in either tumor model.
Participant Demographics
6-9 week old female C3H/He mice
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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