The expression of vascular endothelial growth factor C and its receptors in non-small cell lung cancer
2001
VEGF-C and Its Role in Lung Cancer
Sample size: 62
publication
Evidence: moderate
Author Information
Author(s): Kajita T, Ohta Y, Kimura K, Tamura M, Tanaka Y, Tsunezuka Y, Oda M, Sasaki T, Watanabe Go
Primary Institution: Kanazawa University School of Medicine
Hypothesis
The study investigates the expression of vascular endothelial growth factor C (VEGF-C) and its receptors in non-small cell lung cancer.
Conclusion
VEGF-C is significantly associated with lymphatic invasion and worse outcomes in non-small cell lung cancer patients.
Supporting Evidence
- VEGF-C was expressed in 38.7% of the patients studied.
- A significant positive correlation was found between VEGF-C in cancer cells and VEGFR-3 in vascular endothelial cells.
- VEGF-C expression was significantly associated with lymph node metastasis and lymphatic vessel invasion.
Takeaway
This study found that a protein called VEGF-C is linked to how lung cancer spreads and how well patients do after surgery.
Methodology
Immunohistochemistry was used to assess VEGF-C expression in lung cancer patients.
Participant Demographics
Patients with non-small cell lung cancer.
Digital Object Identifier (DOI)
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