Natural Products as Modulators of Aryl Hydrocarbon Receptor Signaling in Atopic Dermatitis Management
2024

Natural Products for Managing Atopic Dermatitis

publication 10 minutes Evidence: moderate

Author Information

Author(s): Lee Jangho, Choi Hyo-Kyoung, Shin Hee Soon, Kim Gun-Dong

Primary Institution: Korea Food Research Institute

Hypothesis

Natural products can modulate aryl hydrocarbon receptor (AhR) signaling to improve atopic dermatitis (AD) symptoms.

Conclusion

Natural products targeting the AhR pathway show promise as effective and safe alternatives for managing atopic dermatitis.

Supporting Evidence

  • Natural products like curcumin and resveratrol can activate AhR and reduce inflammation.
  • Tapinarof, a topical AhR agonist, has shown efficacy in clinical trials for atopic dermatitis.
  • Natural products have fewer side effects compared to conventional treatments.

Takeaway

Some natural ingredients can help with skin problems like atopic dermatitis by working with a special part of our cells called the aryl hydrocarbon receptor.

Methodology

This review summarizes various studies on natural products that modulate AhR signaling and their effects on atopic dermatitis.

Limitations

The review primarily discusses existing studies without original experimental data.

Digital Object Identifier (DOI)

10.3390/molecules29245951

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