Microsatellite Instability and Gastric Cancer Risk
Author Information
Author(s): Kashiwagi K, Watanabe M, Ezaki T, Kanai T, Ishii H, Mukai M, Hibi T
Primary Institution: Keio University
Hypothesis
Can microsatellite instability (MSI) in patients with chronic gastritis predict the development of gastric adenoma or adenocarcinoma?
Conclusion
MSI in biopsy specimens from patients with chronic gastritis may indicate a risk for developing gastric adenoma and well-differentiated adenocarcinoma.
Supporting Evidence
- Only one of 55 patients with chronic gastritis revealed MSI-H phenotype.
- In six of 17 patients with gastric adenoma or well-differentiated adenocarcinoma, MSI-positive phenotypes were demonstrated.
- All six patients showing MSI had already revealed MSI at the stage of chronic gastritis.
Takeaway
If doctors find certain changes in stomach tissue from patients with chronic gastritis, it might mean those patients are more likely to get stomach cancer later.
Methodology
The study analyzed mutations of five microsatellite loci in patients with chronic gastritis, adenoma, and adenocarcinoma.
Participant Demographics
Patients with chronic gastritis, gastric adenoma, and adenocarcinoma.
Digital Object Identifier (DOI)
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