Comparing Vitamin D2 and D3 Metabolism in Children with Rickets
Author Information
Author(s): Thacher Tom D, Fischer Philip R, Obadofin Michael O, Levine Michael A, Singh Ravinder J, Pettifor John M
Primary Institution: Mayo Clinic
Hypothesis
Vitamin D requirements are increased by dietary calcium deficiency in children with rickets.
Conclusion
Vitamins D2 and D3 similarly increase serum 25(OH)D concentrations in both rachitic and healthy children.
Supporting Evidence
- Children with rickets had significantly lower baseline serum 25(OH)D levels compared to healthy controls.
- Both vitamin D2 and D3 produced similar increases in serum 25(OH)D concentrations.
- Rachitic children showed a marked increase in 1,25(OH)2D in response to vitamin D administration.
Takeaway
This study looked at how two types of vitamin D affect children with rickets. Both types helped increase vitamin levels in the blood.
Methodology
The study involved administering a single oral dose of vitamin D2 or D3 to 49 Nigerian children, measuring changes in vitamin D metabolites over time.
Potential Biases
Potential bias due to differences in severity of rickets between groups receiving different vitamin D forms.
Limitations
The historical comparison group receiving vitamin D2 had different baseline characteristics than those receiving vitamin D3.
Participant Demographics
49 Nigerian children, 28 with active rickets and 21 healthy controls.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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