REDIportal: A Comprehensive Database for A-to-I RNA Editing
Author Information
Author(s): D’Addabbo Pietro, Cohen-Fultheim Roni, Twersky Itamar, Fonzino Adriano, Silvestris Domenico Alessandro, Prakash Ananth, Mazzacuva Pietro Luca, Vizcaino Juan Antonio, Green Andrew, Sweeney Blake, Yates Andy, Lussi Yvonne, Luo Jie, Martin Maria-Jesus, Eisenberg Eli, Levanon Erez Y, Pesole Graziano, Picardi Ernesto
Primary Institution: University of Bari Aldo Moro
Conclusion
REDIportal is a specialized database that collects approximately 16 million A-to-I editing sites, providing a valuable resource for researchers in the field of epitranscriptomics.
Supporting Evidence
- REDIportal collects data from over 9000 RNA sequencing experiments.
- It includes approximately 16 million A-to-I editing sites.
- REDIportal is interconnected with major bioinformatics resources like Ensembl and UniProt.
- The database is designed to facilitate the study of RNA editing in various human disorders.
- REDIportal has been viewed over 23,000 times in the current year.
Takeaway
REDIportal is like a big library that helps scientists find and study tiny changes in RNA that can affect how genes work, which is important for understanding diseases.
Methodology
The database was populated using data from over 9000 RNA sequencing experiments and a rigorous bioinformatics protocol based on the REDItools package.
Limitations
The current release mainly focuses on human data and does not include de novo editing events due to computational restrictions.
Participant Demographics
The study included RNA sequencing data from 549 individuals across 31 tissues and 54 body sites.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website