Plasma Gelsolin Levels in Severe Sepsis
Author Information
Author(s): Wang HaiHong, Cheng BaoLi, Chen QiXing, Wu ShuiJing, Lv Chen, Xie GuoHao, Jin Yue, Fang XiangMing
Primary Institution: The First Affiliated Hospital, School of Medicine, Zhejiang University
Hypothesis
Does plasma gelsolin level predict the severity or clinical outcome of severe sepsis?
Conclusion
Plasma gelsolin may be a valuable marker for severe sepsis, with recovery of levels correlating with clinical improvement.
Supporting Evidence
- Admission plasma gelsolin levels were significantly lower in severe sepsis patients compared to nonseptic critically ill patients and healthy controls.
- Recovery of plasma gelsolin levels was observed in survivors of severe sepsis.
- Admission plasma gelsolin was the only independent factor able to predict the occurrence of severe sepsis.
Takeaway
This study found that patients with severe sepsis have lower levels of a protein called gelsolin, and those who recover show an increase in gelsolin levels.
Methodology
The study measured plasma gelsolin levels in 91 patients with severe sepsis and compared them with nonseptic critically ill patients and healthy controls.
Limitations
The number of patients in the time course study was inadequate for definitive conclusions.
Participant Demographics
Patients were of Chinese Han origin, with a mean age of 68 years for nonsurvivors and 57.5 years for survivors.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website