Lactate vs Non-Lactate Metabolic Acidosis in Critically Ill Patients
Author Information
Author(s): Gunnerson Kyle J, Saul Melissa, He Shui, Kellum John A
Primary Institution: Virginia Commonwealth University
Hypothesis
The various etiologies of metabolic acidosis have unique mortality and morbidity rates associated with them.
Conclusion
Different types of metabolic acidosis are associated with different mortality rates in critically ill patients.
Supporting Evidence
- Patients with metabolic acidosis had a 45% mortality rate compared to 25% for those without.
- Lactic acidosis was associated with the highest mortality rate of 56%.
- Independent predictors of mortality included serum lactate, SIG, phosphate, and age.
Takeaway
Some types of acid in the blood can make people much sicker than others, and knowing which type can help doctors treat them better.
Methodology
An observational cohort study of critically ill patients suspected of having lactic acidosis was conducted in a tertiary care hospital.
Potential Biases
The study could not control for severity of illness between groups, which may affect outcomes.
Limitations
The study is retrospective and limited to available clinical data, which may have excluded some patients with metabolic acidosis due to missing data.
Participant Demographics
The average age of participants was around 57 years, with a mix of male and female patients.
Statistical Information
P-Value
<0.001
Confidence Interval
1.67 to 3.15
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website