ROCKet Trial: Ketamine for Preventing Chronic Pain After Surgery
Author Information
Author(s): Peyton Philip J., Braat Sabine, De Silva Anurika, Story David, Evered Lisbeth, Myles Paul S., Chan Matthew, Schug Stephan, Hogg Malcolm, Holmes Alex, Sidiropoulos Sofia, Leslie Kate
Primary Institution: University of Melbourne
Hypothesis
Does intravenous ketamine reduce the incidence of chronic post-surgical pain at 3 months after surgery compared to placebo?
Conclusion
The ROCKet trial aims to determine if ketamine can effectively prevent chronic post-surgical pain.
Supporting Evidence
- Chronic post-surgical pain is a common complication after major surgery.
- Ketamine is known to have analgesic properties and may help prevent chronic pain.
- Previous small studies suggest a potential benefit of ketamine in reducing chronic pain risk.
Takeaway
This study is testing if giving a medicine called ketamine before and after surgery can help stop people from having pain that lasts a long time after their operation.
Methodology
A multicentre, double-blind, placebo-controlled trial conducted in 36 hospitals, recruiting 4884 patients undergoing major surgery.
Potential Biases
Potential biases related to participant selection and reporting of outcomes.
Limitations
The trial may face challenges in recruitment due to the impact of the COVID-19 pandemic.
Participant Demographics
Adult patients (≥ 18 years) undergoing elective or expedited surgery.
Statistical Information
P-Value
0.001
Confidence Interval
95% CI 0.33–0.76
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website