Comparing CD4+ T Lymphocyte Measurement Methods in HIV Patients
Author Information
Author(s): Toygar Deniz Müge, Akhan Sıla, Sayan Murat, Balcı Sibel
Primary Institution: Kocaeli University
Hypothesis
This study aims to compare standard flow cytometry and point-of-care (POC) CD4+ T lymphocyte measurement methods in terms of cost, effectiveness, reliability, and time.
Conclusion
The POC method shows good consistency with the standard method and is a cost-effective alternative for monitoring CD4+ T lymphocyte counts in resource-limited settings.
Supporting Evidence
- The POC method provided results in just 25 minutes.
- Good consistency was observed for hemoglobin levels and CD4+ T lymphocyte percentage between the two methods.
- CD4+ T lymphocyte counts below 350 cells/mm3 indicate a delayed diagnosis.
Takeaway
Doctors can use a quick and cheap test to check how well a person's immune system is working when they have HIV, which helps them start treatment faster.
Methodology
The study compared CD4+ T lymphocyte counts and hemoglobin levels using flow cytometry and a POC method in 113 HIV patients.
Limitations
The study was not controlled with an HIV-negative patient group.
Participant Demographics
The cohort comprised adult individuals, 18 years or older, with 85% male and 15% female participants.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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