Comparing Two Cancer Treatments in Mice
Author Information
Author(s): Ris H-B, Krueger T, Giger A, Lim C K, Stewart J C M, Althaus U, Altermatt H J
Primary Institution: University of Berne
Hypothesis
The study compares the photosensitizing properties of mTHPC and pegylated mTHPC in treating human tumor xenografts in mice.
Conclusion
Pegylated mTHPC is a more effective photosensitizer than mTHPC for certain types of tumors.
Supporting Evidence
- Both mTHPC and pegylated mTHPC catalyse photosensitized necrosis in mesothelioma xenografts.
- Pegylated mTHPC induced significantly larger photonecrosis than mTHPC in squamous cell xenografts.
- mTHPC led to necrosis of skin and underlying muscle at a drug-light interval of 1 day.
Takeaway
This study looked at two treatments for cancer in mice and found that one treatment worked better than the other for some types of tumors.
Methodology
The study involved administering mTHPC and pegylated mTHPC to mice with human tumors and assessing tumor necrosis and tissue injury.
Limitations
Tissue concentration measurements were of limited use for predicting photosensitization.
Participant Demographics
Nude mice bearing human malignant mesothelioma, squamous cell carcinoma, and adenocarcinoma xenografts.
Digital Object Identifier (DOI)
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