Urine Biomarkers of Risk in Breast Cancer
Author Information
Author(s): Gaikwad Nilesh W., Yang Li, Pruthi Sandhya, Ingle James N., Sandhu Nicole, Rogan Eleanor G., Cavalieri Ercole L.
Primary Institution: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center
Hypothesis
High levels of depurinating estrogen-DNA adducts are present in women at high risk for breast cancer or diagnosed with the disease.
Conclusion
The study suggests that urine levels of depurinating estrogen-DNA adducts could serve as biomarkers for early detection of breast cancer risk.
Supporting Evidence
- High ratios of depurinating DNA adducts to estrogen metabolites were observed in high-risk women and those with breast cancer.
- The study confirmed previous findings of high levels of estrogen-DNA adducts in women at risk for breast cancer.
- Urine samples from healthy controls showed lower levels of these adducts compared to high-risk and breast cancer groups.
Takeaway
This study found that certain substances in urine can help tell if someone is at risk for breast cancer.
Methodology
The study analyzed urine samples from 120 women using ultraperformance liquid chromatography/tandem mass spectrometry.
Limitations
Further larger studies are required to determine how far in advance the urine assay can predict breast cancer.
Participant Demographics
Participants included 40 healthy control women, 40 high-risk women, and 40 women with newly diagnosed breast cancer, aged 23 to 84.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
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