The Impact of Comorbid Sleep-Disordered Breathing on Hospitalization Risk Related to Diabetes and Atherosclerotic Disease: A Retrospective Cohort Analysis
2024

Impact of Sleep-Disordered Breathing on Hospitalization Risk for Diabetes and Heart Disease

Sample size: 519818 publication 10 minutes Evidence: moderate

Author Information

Author(s): Hlynsson Hlynur Davíð, Ong Jason C., Day Joseph, Kauss Thomas, Montazeri Kristófer, Hertzberg Jeffrey, Wickwire Emerson, Hankla Rebecca M., Finnsson Eysteinn, Ágústsson Jón Skírnir, Riney Heidi, Dichtl Wolfgang

Primary Institution: Nox Health, Inc.

Hypothesis

The findings would support the diagnosis of SDB as a risk factor for hospitalizations related to DM, AD, or either.

Conclusion

Comorbid sleep-disordered breathing increases the risk for hospitalizations related to chronic cardiometabolic conditions.

Supporting Evidence

  • 83% of type 2 diabetes patients suffer from undiagnosed sleep apnea.
  • Individuals with OSA have a heightened risk of DM onset compared to those without.
  • Hospitalization is a frequent metric used to indicate worsening disease progression.
  • Post hoc analysis revealed sex differences in the relationship between SDB and future hospitalizations.
  • SDB diagnosis was associated with a 30% increased risk of DM-related hospitalizations.
  • SDB diagnosis was associated with a 23% increased risk of AD-related hospitalizations.
  • Females showed a pattern of significantly elevated risk across all future hospitalization outcomes.
  • Males had a significant relationship between SDB diagnosis and future DM hospitalization only.

Takeaway

People with sleep apnea are more likely to end up in the hospital because of diabetes or heart problems.

Methodology

Retrospective cohort analysis using a large medical claims database over 5 years.

Potential Biases

Potential confounding factors not measured, such as treatment adherence and health literacy.

Limitations

Medical claims data may not accurately reflect disease severity and could have coding inaccuracies.

Participant Demographics

Adults aged 18-64, with a mix of males and females, and various comorbid conditions.

Statistical Information

P-Value

p<0.05

Confidence Interval

95% CI: 1.61–1.67 for DM-related hospitalizations

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/jcm13247715

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