Icaritin Induces Apoptosis in Human Endometrial Cancer Cells
Author Information
Author(s): Tong Jing-Shan, Zhang Qing-Hua, Huang Xin, Fu Xue-Qi, Qi Shu-Tao, Wang Ya-Peng, Hou Yi, Sheng Jun, Sun Qing-Yuan
Primary Institution: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Hypothesis
Icaritin has anti-tumor activity and can induce apoptosis in human endometrial cancer cells.
Conclusion
Icaritin inhibits the growth of endometrial cancer Hec1A cells and induces apoptosis through sustained ERK1/2 activation.
Supporting Evidence
- Icaritin treatment resulted in a dose-dependent reduction of Hec1A cell growth.
- Icaritin induced apoptosis as evidenced by increased TUNEL-positive cells and caspase activation.
- Icaritin treatment led to sustained activation of the ERK1/2 signaling pathway.
Takeaway
Icaritin is a compound that can help kill cancer cells in the uterus by making them stop growing and die.
Methodology
The study involved treating Hec1A cells with various concentrations of icaritin and measuring cell growth and apoptosis through assays.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website