Differences in EGF related radiosensitisation of human squamous carcinoma cells with high and low numbers of EGF receptors
1991
EGF and Radiosensitivity in Human Squamous Carcinoma Cells
Sample size: 4
publication
Evidence: moderate
Author Information
Author(s): T.T. Kwok, R.M. Sutherland
Primary Institution: SRI International
Hypothesis
EGF related radiosensitisation is dependent on EGF receptor density.
Conclusion
Higher EGF receptor density enhances radiosensitivity in certain human squamous carcinoma cells.
Supporting Evidence
- EGF inhibited the growth of A431, CaSki, and HN5 cells, but stimulated the growth of SiHa cells.
- Radiosensitivity enhancement was observed in A431, CaSki, and HN5 cells with EGF treatment.
- Mouse 3T3 cells with low EGF receptors were not sensitised by EGF.
Takeaway
EGF helps some cancer cells be more sensitive to radiation, but it only works if those cells have a lot of EGF receptors.
Methodology
Four human squamous carcinoma cell lines were irradiated and their survival was measured using a clonogenic assay.
Limitations
The study primarily focused on only four cell lines and may not be generalizable to all cancer types.
Participant Demographics
Human squamous carcinoma cell lines.
Statistical Information
Statistical Significance
p<0.05
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