Using MRI to Measure Breast Cancer Response to Chemotherapy
Author Information
Author(s): de Bazelaire Cédric, Calmon Raphael, Thomassin Isabelle, Brunon Clément, Hamy Anne-Sophie, Fournier Laure, Balvay Daniel, Espié Marc, Siauve Nathalie, Clément Olivier, de Kerviler Eric, Cuénod Charles-André
Primary Institution: Hôpital Saint-Louis - Inserm U728 - Université Paris VII
Hypothesis
Breast-MRI performed in high spatial resolution and low temporal resolution allows the measurement of kinetic parameters that can assess the final pathologic response to neoadjuvant chemotherapy in breast cancer.
Conclusion
Changes in kinetic parameters measured with breast-MRI correlate well with pathological findings after chemotherapy.
Supporting Evidence
- MRI changes in kinetic parameters were significantly different between non-responders and responders.
- A decrease in Ve of more than -72% identified non-responders with 73% sensitivity.
- The study found that using measured AIF improved the accuracy of identifying treatment response.
Takeaway
Doctors used MRI to see how well breast cancer treatment worked, and they found that the MRI results matched what they saw when they looked at the cancer after treatment.
Methodology
Breast-MRI was performed on 24 women before and after treatment, measuring kinetic parameters using both measured and theoretical Arterial Input Function.
Potential Biases
Potential bias from the subjective assessment of MRI results and the reliance on a single pathologist for grading.
Limitations
The study had a small sample size and relied on retrospective data.
Participant Demographics
The participants were 24 women with invasive breast cancer, aged 31 to 62 years.
Statistical Information
P-Value
0.0092
Confidence Interval
95% CI: -97%, -80%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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