Hearing Loss from Cisplatinum in Children
Author Information
Author(s): R. Skinner, A.D.J. Pearson, H.A. Amineddine, D.B. Mathias, A.W. Craft
Primary Institution: University of Newcastle upon Tyne
Hypothesis
The study aimed to determine the extent of hearing loss in young people treated with cisplatinum and identify those at greater risk of toxicity.
Conclusion
Cisplatinum can cause significant hearing loss in children, particularly at higher frequencies, with variability among patients.
Supporting Evidence
- Significant hearing loss occurred in all but one patient at 8,000 Hz.
- Hearing loss was greater with higher cumulative doses of cisplatinum.
- Patients who received prior radiotherapy had more severe hearing loss.
- Four patients reported hearing difficulties, with one experiencing school-related issues.
Takeaway
Cisplatinum can make kids' ears hurt and cause them to lose their hearing, especially if they get a lot of it.
Methodology
Audiometry was performed on 22 children and adolescents who received cisplatinum to assess hearing damage.
Limitations
The study had a small sample size and variability in treatment regimens.
Participant Demographics
Participants were aged 7 to 19 years, with a mean age of 13 years; 12 were male.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
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