Prostate tumours from an Asian population: examination of bax, bcl-2, p53 and ras and identification of bax as prognostic marker
2000
Prostate Tumors in Asians: A Study on Genetic Markers
Sample size: 62
publication
Evidence: moderate
Author Information
Author(s): Chia S-J, Tang W-Y, Elnatan J, Yap W-M, Goh H-S, Smith D R
Primary Institution: Tan Tock Seng Hospital
Hypothesis
Ethnicity may play a significant role in prostate tumorigenesis among non-Japanese Asians.
Conclusion
Prostate tumors from non-Japanese Asians are genetically distinct and bax expression is a significant prognostic marker.
Supporting Evidence
- Bax expression was noted in 76% of samples.
- Bax expression was associated with a significantly worse patient prognosis.
- Gene lesions of ras and p53 were rare.
- Apoptotic cells were found in 61% of samples.
Takeaway
The study looked at prostate tumors from Asian patients and found that a protein called bax can help predict how well patients will do.
Methodology
Examined archival samples for protein expression and gene mutations using TUNEL methodology.
Participant Demographics
Asian patients of non-Japanese origin.
Statistical Information
P-Value
P< 0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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