Biomarkers in Nipple Aspirate Fluid and Breast Cancer
Author Information
Author(s): Sauter E R, Ehya H, Babb J, Diamandis E, Daly M, Klein-Szanto A, Sigurdson E, Hoffman J, Malick J, Engstrom P F
Primary Institution: Fox Chase Cancer Center
Hypothesis
Are biologic markers in nipple aspirate fluid associated with residual cancer and tumor size?
Conclusion
Atypical and malignant nipple aspirate fluid cytology are linked to larger tumor sizes and are strong indicators of residual carcinoma.
Supporting Evidence
- Atypical and malignant NAF cytology were significantly associated with residual DCIS or invasive cancer.
- One hundred percent of subjects with malignant NAF cytology had residual carcinoma.
- 88% of subjects with atypical NAF cytology had residual carcinoma.
- The percentage of cells in G2/M was associated with the risk of residual carcinoma.
- Higher DNA index was associated with atypical cytology.
Takeaway
Doctors can check a fluid from the nipple to see if there are signs of breast cancer, and certain results can tell if the cancer is still there or if it's bigger.
Methodology
Nipple aspiration was performed on 97 specimens, and various markers were evaluated for their association with residual cancer and tumor size.
Participant Demographics
Non-Asian women aged 30 to 72.
Statistical Information
P-Value
P = 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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