Selective Glucocorticoid Receptor Antagonist Reduces Weight Gain in Mice
Author Information
Author(s): Asagami Tomoko, Belanoff Joseph K., Azuma Junya, Blasey Christine M., Clark Robin D., Tsao Philip S.
Primary Institution: Stanford University
Hypothesis
Can a selective glucocorticoid receptor antagonist block dietary-induced weight gain and increase insulin sensitivity in mice?
Conclusion
The selective glucocorticoid receptor antagonist CORT 108297 significantly reduced weight gain and steady state plasma glucose in mice on a high-fat, high-sugar diet.
Supporting Evidence
- Mice receiving CORT 108297 gained significantly less weight compared to the vehicle group.
- Steady state plasma glucose was significantly lower in mice treated with CORT 108297 and mifepristone.
- The study suggests that the effects of CORT 108297 on weight gain and insulin sensitivity may be independent.
Takeaway
This study found that a new drug can help mice not gain as much weight when they eat a lot of fat and sugar.
Methodology
Forty male mice were fed a high-fat, high-sugar diet for 4 weeks and treated with different doses of CORT 108297, mifepristone, or vehicle.
Limitations
The study was a proof-of-concept design and not statistically powered to evaluate a large number of outcome variables.
Participant Demographics
Ten-week-old, male, C57BL/6J mice.
Statistical Information
P-Value
< .0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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