Expressions of Fas ligand and other apoptosis-related genes and their prognostic significance in epithelial ovarian neoplasms
2000
Prognostic Significance of Apoptosis-Related Genes in Ovarian Neoplasms
Sample size: 132
publication
Evidence: moderate
Author Information
Author(s): Munakata S, Enomoto T, Tsujimoto M, Otsuki Y, Miwa H, Kanno H, Aozasa K
Primary Institution: Osaka University Medical School
Hypothesis
The expression of apoptosis-related proteins in ovarian epithelial neoplasms has clinical relevance.
Conclusion
The study found that certain expressions of apoptosis-related proteins are linked to prognosis in ovarian neoplasms.
Supporting Evidence
- bcl-2 expression was observed in 39% of adenoma cases, 15% of low potential malignancy cases, and 19% of carcinoma cases.
- Fas L expression was found in 3% of adenoma cases, 36% of low potential malignancy cases, and 67% of carcinoma cases.
- Cases expressing Fas L showed a less favorable prognosis in carcinomas.
Takeaway
The study looked at how certain proteins in ovarian tumors can help predict how well a patient might do.
Methodology
Immunohistochemistry was used to examine the expression of apoptosis-related proteins in ovarian epithelial neoplasms.
Participant Demographics
The study included 36 cases with adenoma, 33 with low potential malignancy, and 63 with carcinomas.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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