Study of the SAMD9 Gene in Aggressive Fibromatosis
Author Information
Author(s): Catherine F. Li, Jeffrey R. MacDonald, Robert Y. Wei, Jocelyn Ray, Kimberly Lau, Christopher Kandel, Rachel Koffman, Sherilyn Bell, Stephen W. Scherer, Benjamin A. Alman
Primary Institution: The Hospital for Sick Children
Hypothesis
SAMD9 is down-regulated in aggressive fibromatosis and plays a role in regulating cell proliferation.
Conclusion
SAMD9 and SAMD9L are novel genes that regulate cell proliferation and suppress the neoplastic phenotype.
Supporting Evidence
- SAMD9 is expressed at lower levels in aggressive fibromatosis and some cases of breast and colon cancer.
- Over-expression of SAMD9 in colon cancer cells reduced tumor volume in mice.
- SAMD9 is lost in the mouse lineage due to a unique genomic rearrangement.
Takeaway
Scientists found a gene called SAMD9 that helps control how fast cells grow, and it's not working properly in some tumors.
Methodology
The study used suppression subtractive hybridization to compare gene expression in cell cultures from aggressive fibromatosis tumors.
Limitations
The study did not investigate the regulation of expression in SAMD9 and SAMD9L.
Participant Demographics
Patients with sporadic aggressive fibromatosis, colon cancer, and breast cancer.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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