Radiation-enhancement of MDA-MB-231 breast cancer cell invasion prevented by a cyclooxygenase-2 inhibitor
2011
Radiation and Breast Cancer Cell Invasion
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Benoit Paquette, Therriault H, Desmarais G, Wagner R, Royer R, Bujold R
Primary Institution: Université de Sherbrooke
Hypothesis
Does irradiation of fibroblasts enhance the invasiveness of breast cancer cells through COX-2 activity?
Conclusion
Radiation-enhancement of breast cancer cell invasion can be prevented by a COX-2 inhibitor.
Supporting Evidence
- Irradiated fibroblasts increased the invasiveness of MDA-MB-231 cells by 5.8-fold.
- The COX-2 inhibitor NS-398 completely prevented the radiation-enhancement of cancer cell invasion.
- COX-2 expression was enhanced by irradiation of fibroblasts.
Takeaway
When breast cancer cells are exposed to irradiated fibroblasts, they become more invasive, but this can be stopped with a specific medicine.
Methodology
The study used invasion assays with irradiated fibroblasts and breast cancer cell lines to assess invasiveness and COX-2 activity.
Limitations
The study was conducted in vitro, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p=0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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