Erectogenic Effects of Clerodendron capitatum
Author Information
Author(s): Abdelwahab Siddig Ibrahim, Mohamed Abdelwahab Hassan, Mohamed Osama Yousif, Oall Mahjoub, Taha Manal Mohamed Elhassan, Mohan Syam, Noordin Mohamed Ibrahim, Mustafa Mohd Rais, Alkharfy Khalid M.
Primary Institution: University of Malaya
Hypothesis
The study investigates the erectogenic properties of Clerodendron capitatum and its potential to inhibit phosphodiesterase type-5 (PDE-5).
Conclusion
Clerodendron capitatum has a relaxant effect on corpus cavernosum smooth muscle, attributed to the inhibition of PDE-5.
Supporting Evidence
- C. capitatum extract caused significant concentration-dependent relaxation of CCSM.
- The ID50 for PDE-5 inhibition by C. capitatum was found to be 0.161 mg/ml.
- The extract did not interfere with adrenergic or cholinergic receptor activities.
Takeaway
This study found that a plant called Clerodendron capitatum can help with erections by blocking a certain enzyme in the body.
Methodology
The study involved testing the effects of Clerodendron capitatum on isolated rabbit corpus cavernosum smooth muscle and its inhibitory activity on PDE-5 in vitro.
Participant Demographics
Sexually mature male New Zealand White rabbits and guinea pigs were used in the experiments.
Statistical Information
P-Value
0.161 mg/ml
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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