Effects of Naproxen on Dental Implant Healing
Author Information
Author(s): Kumchai Hattanas, Taub Daniel I., Tomlinson Ryan E.
Primary Institution: Thomas Jefferson University
Hypothesis
The use of NSAIDs in the immediate postoperative period would lead to decreased implant stability due to impaired dental implant osseointegration.
Conclusion
This pilot study provides effect sizes and sample size estimates for future studies to determine recommendations regarding NSAID usage following dental implant surgery.
Supporting Evidence
- Subjects receiving naproxen had a modest increase in ISQ values, while those on placebo had a much larger increase.
- 55% more marginal bone loss was observed in the naproxen group at 4 weeks compared to the placebo group.
- 68% of patients with early failed dental implants reported a history of NSAIDs usage after surgery.
Takeaway
This study looked at whether taking naproxen after getting dental implants helps or hurts the healing process. It found that naproxen didn't make a big difference in healing compared to a placebo.
Methodology
Subjects receiving a maxillary dental implant were randomized to take naproxen or placebo for 7 days after surgery, with implant stability assessed at multiple follow-up visits.
Potential Biases
Potential bias due to the small number of subjects and the lack of standardization in implant systems.
Limitations
The study had a small sample size and variability in implant sites, which may affect the results.
Participant Demographics
Subjects were aged 25 to 76 years, with a mix of males and females.
Statistical Information
Statistical Significance
p≥0.05
Digital Object Identifier (DOI)
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