Pneumococcal Surface Protein A in Colombian Children
Author Information
Author(s): Maria Claudia Vela Coral, Nacxiry Fonseca, Elizabeth Castaneda, Jose Luis Di Fabio, Susan K. Hollingshead, David E. Briles
Primary Institution: Instituto Nacional de Salud
Hypothesis
A human PspA vaccine covering a few PspA families could be broadly effective.
Conclusion
The study found that 97.5% of Colombian Streptococcus pneumoniae isolates belong to PspA families 1 and 2, suggesting a targeted vaccine could be effective.
Supporting Evidence
- 97.5% of Colombian isolates belong to PspA families 1 and 2.
- All invasive isolates except one were classified into these two families.
- The distribution of PspA families in Colombia is similar to that in North America and Europe.
Takeaway
Most of the bacteria from Colombian children that cause serious infections belong to two main groups, which means a vaccine could work well for many kids.
Methodology
The study analyzed 40 invasive S. pneumoniae isolates from Colombian children using PCR and serologic techniques to determine PspA families.
Limitations
The study only included Colombian isolates and did not consider antimicrobial susceptibility patterns in the selection of isolates.
Participant Demographics
Colombian children under 5 years of age.
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