Study of Melanocortin Receptors in Lamprey
Author Information
Author(s): Haitina Tatjana, Klovins Janis, Takahashi Akiyoshi, Löwgren Maja, Ringholm Aneta, Enberg Johan, Kawauchi Hiroshi, Larson Earl T, Fredriksson Robert, Schiöth Helgi B
Primary Institution: Department of Neuroscience, Unit of Pharmacology, Uppsala University
Hypothesis
The study aims to identify ancestral melanocortin receptors in the river lamprey.
Conclusion
The presence of melanocortin receptors in agnathans indicates early signs of specific functions of these receptor subtypes.
Supporting Evidence
- The lamprey MCa receptor binds both lamprey and human MSH peptides.
- The lamprey MCb receptor was found in liver, heart, and skeletal muscle.
- Molecular clock analysis suggested that the receptors diverged more than 400 million years ago.
Takeaway
Scientists found two types of receptors in lampreys that help control body weight and color, showing that these receptors have been around for a long time.
Methodology
The study involved cloning and pharmacological characterization of two melanocortin receptors from river lamprey.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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