Identification of the ACE3 Gene in Mammals
Author Information
Author(s): Rella Monika, Elliot Joann L, Revett Timothy J, Lanfear Jerry, Phelan Anne, Jackson Richard M, Turner Anthony J, Hooper Nigel M
Primary Institution: University of Leeds
Hypothesis
Is there a third homologue of angiotensin-converting enzyme (ACE) in mammals?
Conclusion
The ACE3 gene encodes a novel ACE-like protein in several mammals, but in humans, it appears to be a pseudogene.
Supporting Evidence
- ACE3 is located on the same chromosome as ACE in several mammals.
- In mouse, rat, cow, and dog, ACE3 has mutations that likely prevent it from functioning as a protease.
- No evidence of ACE3 expression was found in humans, indicating it is a pseudogene.
Takeaway
Scientists found a new gene called ACE3 in some mammals that is similar to ACE, but it doesn't work in humans because it's broken.
Methodology
The study involved genomic analysis, sequence alignment, and RT-PCR to identify and characterize the ACE3 gene.
Limitations
The study primarily focuses on genomic data and lacks functional assays for ACE3 activity.
Digital Object Identifier (DOI)
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