Soluble interleukin-18 receptor complex as a biomarker in rheumatoid arthritis
Author Information
Author(s): Takei Satoko, Hoshino Tomoaki, Matsunaga Kazuko, Sakazaki Yuki, Sawada Masanori, Oda Hanako, Takenaka Shin-ichi, Imaoka Haruki, Kinoshita Takashi, Honda Seiyo, Ida Hiroaki, Fukuda Taka-aki, Aizawa Hisamichi
Primary Institution: Kurume University School of Medicine
Hypothesis
The soluble interleukin-18 receptor α complex could serve as a biomarker for rheumatoid arthritis.
Conclusion
The sIL-18Rα complex could be a potentially useful biomarker for the diagnosis of rheumatoid arthritis.
Supporting Evidence
- The serum levels of sIL-18Rα complex in RA patients were significantly higher than in healthy controls.
- ROC-AUC analysis indicated that the serum concentration of sIL-18Rα was significantly diagnostic of RA.
- Treatment with etanercept significantly decreased levels of sIL-18Rα in RA patients.
Takeaway
This study found a new protein in the blood of people with rheumatoid arthritis that could help doctors diagnose the disease better.
Methodology
The study isolated the sIL-18Rα complex from human serum and compared levels in patients with rheumatoid arthritis to various control groups.
Participant Demographics
145 patients with rheumatoid arthritis (24 males, 121 females) and 67 healthy controls.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website