The Role of Ribosomal Proteins in Viral Infections
Author Information
Author(s): Zhao Zhongwei, Ruan Shan, Li Yang, Qi Te, Qi Ying, Huang Yujing, Liu Zhongyang, Ruan Qiang, Ma Yanping
Primary Institution: Shengjing Hospital of China Medical University
Hypothesis
How do eukaryotic ribosomal proteins (RPs) influence viral infections beyond their traditional role in protein synthesis?
Conclusion
Ribosomal proteins play significant extra-ribosomal roles in regulating immune responses and viral replication during infections.
Supporting Evidence
- Ribosomal proteins are crucial for both protein synthesis and regulating cellular processes during viral infections.
- Extra-ribosomal functions of ribosomal proteins include modulating immune responses and influencing viral replication.
- Ribosomal proteins can act as receptors for viruses, facilitating their entry into host cells.
- Some ribosomal proteins have been shown to enhance or inhibit viral replication through their interactions with viral components.
Takeaway
Ribosomal proteins help our cells fight off viruses and can also help viruses grow, showing they have important jobs outside of making proteins.
Methodology
This review synthesizes existing research on the extra-ribosomal functions of ribosomal proteins during viral infections.
Limitations
The review does not include studies lacking direct evidence of specific extra-ribosomal functions.
Digital Object Identifier (DOI)
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