Food Composition and Testosterone Levels
Author Information
Author(s): Peter G Schnabel, Wilma Bagchus, Holger Lass, Torben Thomsen, T B Paul Geurts
Primary Institution: Department of Clinical Pharmacology and Kinetics NV Organon, Oss, the Netherlands
Hypothesis
The study investigates how different food compositions affect the absorption of oral testosterone undecanoate.
Conclusion
A meal with approximately 19 g of lipid effectively increases the absorption of testosterone from oral testosterone undecanoate.
Supporting Evidence
- The bioavailability of testosterone increased significantly with meals containing higher lipid content.
- Meals with less than 19 g of lipid resulted in low testosterone absorption.
- All subjects completed the study without serious adverse events.
Takeaway
Eating the right amount of fat with testosterone pills helps your body absorb the medicine better.
Methodology
An open-label, single-centre, four-way crossover study with 24 postmenopausal women receiving 80 mg of testosterone undecanoate after different meals.
Potential Biases
Potential bias due to the open-label design and the specific demographic of participants.
Limitations
The study only included postmenopausal women, which may limit the generalizability of the results to other populations.
Participant Demographics
24 healthy postmenopausal women aged 45-65 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
0.80–1.20
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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