HTRA3 Expression in Rhesus Monkey Ovary and Endometrium
Author Information
Author(s): Marissa A Bowden, Li Ying, Liu Yi-Xun, Jock K Findlay, Lois A Salamonsen, Guiying Nie
Primary Institution: Prince Henry's Institute of Medical Research
Hypothesis
HTRA3 may be involved in folliculogenesis and luteinisation in the primate ovary.
Conclusion
HTRA3 is associated with folliculogenesis and luteinisation in the rhesus monkey ovary and plays a role in endometrial function during early pregnancy.
Supporting Evidence
- HTRA3 mRNA was detected in various tissues including the ovary and uterus.
- HTRA3 protein expression increased significantly in granulosa cells during follicle maturation.
- HTRA3 was strongly expressed in maternal decidual cells during early pregnancy.
Takeaway
HTRA3 is a protein that helps in the growth of eggs in monkeys and is important for pregnancy.
Methodology
HTRA3 mRNA levels were determined by semiquantitative RT-PCR and protein expression was assessed by immunohistochemistry.
Participant Demographics
Rhesus monkeys (Macaca mulatta), n = 16 (7 non-pregnant, 5 pregnant, and 4 endometrial samples).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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