Fractionated γ-irradiation renders tumour cells more responsive to apoptotic signals through CD95
1999
Radiation Makes Cancer Cells More Sensitive to Death Signals
publication
Author Information
Author(s): Sheard M A, Krammer P H, Zaloudik J
Primary Institution: Masaryk Memorial Cancer Institute
Hypothesis
Can fractionated γ-irradiation enhance the apoptotic response of tumor cells to CD95 signaling?
Conclusion
Fractionated γ-irradiation increases the responsiveness of carcinoma cells to CD95-mediated signals.
Supporting Evidence
- Tumor cells can be made more sensitive to death signals with the right treatment.
- Fractionated radiation leads to a longer period of increased CD95 expression in certain cell lines.
Takeaway
When cancer cells are treated with radiation in smaller doses over time, they become better at responding to signals that tell them to die.
Methodology
Carcinoma cells were treated with single-dose or fractionated γ-irradiation and then assessed for responsiveness to CD95 signals.
Digital Object Identifier (DOI)
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