The spindle position checkpoint in budding yeast

publication Evidence: moderate

Author Information

Author(s): Simonetta Piatti, Marianna Venturetti, Elena Chiroli, Roberta Fraschini

Primary Institution: Dipartimento di Biotecnologie e Bioscienze, Universita' di Milano-Bicocca

How does the spindle position checkpoint regulate mitotic exit in budding yeast?

The study highlights the crucial role of the mother cell in controlling mitotic exit in response to spindle mispositioning.

The spindle position checkpoint delays mitotic exit to correct spindle misalignment.
Cdc14 is a key protein that promotes mitotic exit in budding yeast.
Tem1 is regulated by several proteins that ensure proper timing of mitotic exit.
Bub2 and Bfa1 are crucial for maintaining the spindle position checkpoint.
Recent data suggest that the mother cell plays a significant role in controlling mitotic exit.

This study explains how yeast cells make sure they divide correctly by checking if their spindles are in the right place before they split.

This review synthesizes recent data on the spindle position checkpoint and its regulators in budding yeast.

The study does not provide experimental data to definitively prove the proposed models.

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