AP-2α Expression and Survival in Ovarian Cancer
Author Information
Author(s): Anttila M A, Kellokoski J K, Moisio K I, Mitchell P J, Saarikoski S, Syrjänen K, Kosma V-M
Primary Institution: University of Kuopio and Kuopio University Hospital
Hypothesis
The expression of transcription factor AP-2α is correlated with survival in epithelial ovarian cancer.
Conclusion
High cytoplasmic expression of AP-2α is associated with better overall survival, while nuclear expression combined with low cytoplasmic expression increases the risk of dying from ovarian cancer.
Supporting Evidence
- AP-2α expression was analyzed in 303 epithelial ovarian carcinomas.
- High cytoplasmic AP-2α expression favored overall survival.
- Nuclear AP-2α expression combined with low cytoplasmic expression increased the risk of dying from ovarian cancer.
Takeaway
This study found that how a protein called AP-2α is expressed in ovarian cancer can help predict how long patients might live.
Methodology
The study analyzed AP-2α expression in ovarian carcinomas using immunohistochemistry and correlated it with survival and clinicopathological variables.
Statistical Information
P-Value
P = 0.002
Confidence Interval
95% CI 1.13–2.18
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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