Early Immune Response to Anti-PD1 Therapy in Lung Cancer Patients
Author Information
Author(s): Gelibter Alain, Tuosto Lucrezia, Asquino Angela, Siringo Marco, Sabatini Arianna, Zizzari Ilaria Grazia, Pace Angelica, Scirocchi Fabio, Valentino Flavio, Bianchini Serena, Caponnetto Salvatore, Paoli Donatella, Bellati Filippo, Santini Daniele, Nuti Marianna, Rughetti Aurelia, Napoletano Chiara
Primary Institution: Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
Hypothesis
This study aims to analyze the activating and inhibiting immune cells of NSCLC patients before and during therapy to identify patients who will benefit from immunotherapies.
Conclusion
Immunotherapy improved the immunological fitness of patients who benefited from treatment, shifting the immune balance towards activation.
Supporting Evidence
- Immunotherapy significantly increased the levels of Ki67+ T cells and non-suppressive Tregs.
- Responding patients showed a significant increase in Ki67+ and CD8+ T cells after the first treatment.
- A low ratio of Tregs/CD137+ T cells correlated with a positive response to therapy.
- Soluble PD1 levels increased after the first cycle of immunotherapy.
Takeaway
The study found that a type of treatment for lung cancer helps the body's immune system fight the cancer better, especially in patients who respond well to the treatment.
Methodology
The study analyzed immune cell changes in 48 NSCLC patients before and after the first cycle of immunotherapy using cytofluorimetry and Luminex assays.
Potential Biases
Potential biases may arise from the small sample size and the variability in treatment regimens.
Limitations
The study had a limited number of patients and treatment heterogeneity.
Participant Demographics
{"age":{"median":69.5,"under_75":35,"over_75":13},"sex":{"male":38,"female":10},"smoking_status":{"smokers":40,"non_smokers":8},"histotype":{"adenocarcinoma":38,"squamous":10}}
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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