Analysis of the Preventive Effect of Lonicera caerulea Pomace and Its Isolated Components on Colitis in Mice Based on Gut Microbiota and Serum Metabolomics
2024
Effects of Lonicera caerulea Pomace on Colitis in Mice
Sample size: 40
publication
10 minutes
Evidence: high
Author Information
Author(s): Zhou Zinuo, Huang Xinwen, Zhang Baixi, Rufián-Henares José Ángel
Primary Institution: Jiangnan University
Hypothesis
Does Lonicera caerulea pomace and its components prevent colitis in mice?
Conclusion
Lonicera caerulea pomace significantly alleviates colitis symptoms in mice, more effectively than its polyphenol-rich extract.
Supporting Evidence
- Lonicera caerulea pomace intake significantly restored 15 metabolites in colitis mice.
- The pomace improved five metabolic pathways related to colitis.
- Intake of LCP significantly increased colon length compared to the DSS group.
- Histopathological scores showed significant improvement in the DSS + LCP group.
- Microbiota analysis indicated increased diversity in the DSS + LCP group.
Takeaway
Eating Lonicera caerulea pomace can help mice with a tummy ache called colitis feel better.
Methodology
Mice were fed Lonicera caerulea pomace and its extracts, then colitis was induced using DSS, followed by analysis of gut microbiota and serum metabolites.
Limitations
The study was conducted only in mice, and the effects in humans are not yet known.
Participant Demographics
C57BL/6J mice, 8 per group.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website