Effect of Bifidobacterium lactis HN019 on Gut Transit Time and Symptoms
Author Information
Author(s): Waller Philip A, Gopal Pramod K, Leyer Gregory J, Ouwehand Arthur C, Reifer Cheryl, Stewart Morgan E, Miller Larry E
Primary Institution: Accurate Clinical Research, Houston, TX, USA
Hypothesis
Can Bifidobacterium lactis HN019 supplementation shorten whole gut transit time and reduce functional gastrointestinal symptoms in adults?
Conclusion
Daily B. lactis HN019 supplementation is well tolerated, decreases whole gut transit time in a dose-dependent manner, and reduces the frequency of functional gastrointestinal symptoms in adults.
Supporting Evidence
- High dose group showed a significant reduction in WGTT from 49 ± 30 to 21 ± 32 hours.
- Low dose group showed a significant reduction in WGTT from 60 ± 33 to 41 ± 39 hours.
- Eight out of nine functional GI symptoms significantly decreased in the high dose group.
- Seven out of nine functional GI symptoms significantly decreased in the low dose group.
- Only two symptoms showed significant improvement in the placebo group.
Takeaway
Taking a probiotic called B. lactis HN019 can help your tummy work better and make you feel less gassy or uncomfortable.
Methodology
100 adults with functional GI symptoms were randomized to receive either high dose, low dose, or placebo of B. lactis HN019 for 14 days, with WGTT assessed by X-ray.
Potential Biases
None reported.
Limitations
Results are specific to B. lactis HN019 and may not apply to other probiotic strains; some subjects had no observable markers on follow-up radiographs.
Participant Demographics
Mean age 44 years; 64% female.
Statistical Information
P-Value
p < 0.001
Confidence Interval
95% CI not calculated for all groups.
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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