Determination of an optimal dosing regimen for aspirin chemoprevention of 1,2-dimethylhydrazine-induced colon tumours in rats
1999
Aspirin's Role in Preventing Colon Cancer in Rats
publication
Evidence: moderate
Author Information
Author(s): Barnes C J, Lee M
Primary Institution: University of Texas Health Science Center, Veterans Affairs Medical Center
Hypothesis
Can an optimal dosing regimen of aspirin effectively prevent colon tumors induced by 1,2-dimethylhydrazine in rats?
Conclusion
Aspirin must be administered continuously during the entire carcinogenic period to effectively reduce tumor incidence and volume.
Supporting Evidence
- Aspirin treatment throughout the entire carcinogenic period significantly reduced tumor incidence and volume.
- Intermittent aspirin dosing increased tumor number and/or volume.
Takeaway
Giving aspirin all the time helps stop cancer from growing in rats, but taking it only sometimes can make it worse.
Methodology
Colon tumors were induced in rats, and aspirin was administered in the diet at 500 p.p.m. during various stages of colon carcinogenesis.
Participant Demographics
Rats were used as the study participants.
Digital Object Identifier (DOI)
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