Insulin-Mimetic Action of Rhoifolin and Cosmosiin from Citrus grandis Leaves
Author Information
Author(s): Rao Yerra Koteswara, Lee Meng-Jen, Chen Keru, Lee Yi-Ching, Wu Wen-Shi, Tzeng Yew-Min
Primary Institution: Institute of Biochemical Sciences and Technology, Chaoyang University of Technology
Hypothesis
Can rhoifolin and cosmosiin from Citrus grandis leaves enhance adiponectin secretion and insulin receptor phosphorylation in 3T3-L1 cells?
Conclusion
Rhoifolin and cosmosiin from red wendun leaves may help treat diabetes by increasing adiponectin secretion and insulin receptor activity.
Supporting Evidence
- Rhoifolin and cosmosiin increased adiponectin secretion in a dose-dependent manner.
- 5 μM of rhoifolin and 20 μM of cosmosiin showed similar effects to insulin on insulin receptor phosphorylation.
- GLUT4 translocation was enhanced by rhoifolin and cosmosiin treatment.
Takeaway
This study found that two compounds from a plant can help the body use insulin better, which is important for people with diabetes.
Methodology
The study used differentiated 3T3-L1 adipocytes to test the effects of rhoifolin and cosmosiin on adiponectin secretion and insulin receptor phosphorylation.
Limitations
The study does not explore the long-term effects of these compounds or their mechanisms in vivo.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website