Hevin and Its Role in Cancer
Author Information
Author(s): Claeskens A, Ongenae N, Neefs J M, Cheyns P, Kaijen P, Cools M, Kutoh E
Primary Institution: Department of Biochemistry, Biotechnology, Immunology, Janssen Research Foundation
Hypothesis
Hevin is a negative regulator of cell growth and proliferation.
Conclusion
Hevin may act as a tumor suppressor gene and could be a potential target for cancer diagnosis and therapy.
Supporting Evidence
- Hevin was cloned from human omental adipose tissue.
- Hevin expression was down-regulated in most neoplastic cells or tissues tested.
- Hevin was shown to inhibit cell proliferation in cancer cells.
- Hevin may form a homodimer in vitro.
Takeaway
Hevin is a protein that helps control how fast cells grow, and it is often found in lower amounts in cancer cells.
Methodology
The study involved cloning Hevin cDNA, analyzing its expression in various tissues, and measuring DNA synthesis in cancer cells after expressing Hevin.
Limitations
The mechanism and physiological meaning of Hevin's down-regulation are not known.
Participant Demographics
Patients with omental adipose tissue were used for cloning Hevin cDNA.
Digital Object Identifier (DOI)
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