Hypoalbuminemia and Cisplatin-Induced Acute Kidney Injury
Author Information
Author(s): Yin Wen-Jun, Huang Yu-Jie, Zhu Qing, Lin Xiao-Qing, Piao Hui-Ling, Yu Qian-Qian, Lai Chang-Hong, Zhou Guang-Liang, Zhou Ling-Yun, Liu Kun, Zuo Xiao-Cong, Zuo Shan-Ru
Primary Institution: The Third Xiangya Hospital, Central South University, Changsha, Hunan, China
Hypothesis
Hypoalbuminemia is an independent risk factor for cisplatin-induced acute kidney injury (CIA).
Conclusion
Hypoalbuminemia is confirmed as an independent risk factor for CIA, suggesting that monitoring and adjusting serum albumin levels may reduce the risk of kidney injury in patients receiving cisplatin.
Supporting Evidence
- The meta-analysis included six studies with a total of 4,359 cases showing a significant association between hypoalbuminemia and CIA.
- Both hospitals found a significant association between hypoalbuminemia and CIA with odds ratios of 2.76 and 2.88.
- The study confirmed hypoalbuminemia as an independent risk factor for CIA through both meta-analysis and real-world data.
Takeaway
If you have low albumin levels while getting cisplatin treatment, you might be at a higher risk of kidney problems, so doctors should check your albumin levels regularly.
Methodology
The study used a random-effects meta-analysis and a dual-center retrospective analysis of patients treated with cisplatin to assess the relationship between hypoalbuminemia and CIA.
Potential Biases
Most studies had a moderate risk of bias.
Limitations
The study is observational and may involve reverse causality; there is also significant statistical heterogeneity among the included studies.
Participant Demographics
The study included 30,666 cancer patients from two hospitals, with an average age of 55.2 years and varying percentages of male and female participants.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI, 1.37–3.32
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website