Improving Luteal Function with Blood Flow Treatments
Author Information
Author(s): Takasaki Akihisa, Tamura Hiroshi, Taniguchi Ken, Asada Hiromi, Taketani Toshiaki, Matsuoka Aki, Yamagata Yoshiaki, Shimamura Katsunori, Morioka Hitoshi, Sugino Norihiro
Primary Institution: Yamaguchi University Graduate School of Medicine
Hypothesis
Can increasing blood flow in the corpus luteum improve luteal function in women with luteal phase defect?
Conclusion
Vitamin E or L-arginine treatment improved luteal function by decreasing blood flow impedance in the corpus luteum.
Supporting Evidence
- Vitamin E improved CL-RI in 83% of patients.
- L-arginine improved CL-RI in all patients treated.
- HCG improved CL-RI in all patients treated.
Takeaway
This study found that giving certain treatments can help improve blood flow in a part of the ovary, which helps women who have trouble with their menstrual cycles.
Methodology
Patients with luteal phase defect and high blood flow impedance were treated with vitamin E, L-arginine, melatonin, or HCG, and blood flow and hormone levels were measured.
Potential Biases
Potential selection bias due to non-randomized treatment assignment.
Limitations
The study is a pilot with a small sample size and lacks a randomized controlled trial design.
Participant Demographics
66 women aged 24-41, non-smokers, free from major medical illnesses.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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